The Par-4-GRP78 TRAIL, more twists and turns

Twists and turns

Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape.

The twists and turns of enzyme function.

Twists and turns in protein folding

to make the best possible use of the bounty of genome information that is becoming available at an ever increasing pace. If only one could feed each new sequence into a computer and let it wriggle the polypeptide chain about in silico, to see what three-dimensional structure it ends up with, the proteins encoded by the genomes already sequenced would soon become an open book. But sadly, althoug...

Cell Death: A New Par-4 the TRAIL

The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum stress.

Twists and turns in the body: an imaging spectrum.

Life is full of twists and turns. These surprises can sometimes be wonderfully invigorating. Twists and turns can also occur in the body, however, sometimes with dangerous consequences. Torsion and volvulus are important causes of acute abdominal pain. The clinical symptoms and signs associated with torsion and volvulus are often non-specific and are difficult to diagnose clinically. Clinicians...